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Site NavigationEupedia Top > Europe Guide Top > Genetics > Health in your genes

Genetically inherited traits, conditions and diseases

What can DNA tell you about yourself ?

Cardiovascular diseases Autoimmune diseases Other diseases
Cancers Neuro-psychological conditions Physical & health-related traits

Recommended reading on how genome-wide association studies are used to identify genetic variants associated with human diseases : Nature : Finding the missing heritability of complex diseases

List of miscellaneous diseases with the associated genes

=> 36 other diseases and 151 SNP's listed.

Risk alleles : Substantially lower risk (over 3x less), moderately lower risk (up to 3x less), normal, slightly higher risk (up to 3x more), greatly increased risk (over 3x more). Normal alleles marked with a * mean that the person is a carrier of the disease. Depending on the testing company, sometimes A is reported as T, and G is reported as C, or vice-versa.

Testing companies : 1 = 23andMe ; 2 = DeCODEme
Bold numbers indicate that the SNP is part of the official report, and is therefore likely to be more reliable. Only SNP's in the official report are listed for deCODEme. However, as deCODEme tests almost twice more SNP's than 23andMe, most of the SNP's tested by 23andMe are also tested by deCODEme.

Description
Chromosome
Gene
SNP
Risk alleles
Tested by*
Links
 
Acid reflux disease (GERD)
10
CYP2C19
Acid reflux disease
(Eosinophilic esophagitis)
7
CCL26
rs2302009
AA, AC, CC
1
Acute intermittent porphyria
11
HMBS
 
 
mtDNA
 
Age-related Macular Degeneration
1
CFH
rs800292
CC, CT, TT
1, 2
rs3753394
CC, CT, TT
1, 2
rs1329428
AA, AG, GG
1, 2
rs1061147
AA, AC, CC
1, 2
rs1061170
CC, CT, TT
1
 
4
TLR3
rs3775291
AA, AG, GG
1
 
 
6
C2
rs547154
GG, GT, TT
1
 
10
HTRA1
rs11200638
AA, AG, GG
1
     
rs932275
AA, AG, GG
1, 2
 
10
ARMS2
rs10490924
GG, GT, TT
1
     
rs3750847
CC, CT, TT
1
 
 
19
C3
rs2230199
CC, CG, GG
1
 
Alzheimer's Disease
2
EIF2AK2
rs2254958
CC, CT, TT
1
 
3
MME
rs1836915
 
 
6
TNF
rs1799724
CC, CT, TT
1
 
 
9
DAPK1
rs4878104
1
 
 
rs4877365
1
 
 
9
GOLM1
rs10868366
GG, GT, TT
 
 
rs7019241
CC, CT, TT
 
 
9
intergenic
rs9886784
AA, AC, CC
 
 
10
CALHM1
rs2986017
CC, CT, TT
 
10
PLAU
rs2227564
1, 2
rs2227562
1, 2
 
11
GAB2
rs2373115
GG, GT, TT
1
 
 
11
BDNF
rs6265
AA, AG, GG
1
 
     
rs11030104
1
 
     
rs2049045
1
 
 
11
SORL1
rs2070045
GG, GT, TT
1
 
 
rs661057
CC, CT, TT
1
 
 
rs668387
CC, CT, TT
1
 
 
rs689021
AA, AG, GG
1
 
 
rs641120
AA, AG, GG
1
 
 
rs12285364
CC, CT, TT
1
 
 
12
A2M
rs669
AA, AG, GG
1
 
 
12
OLR1
rs1050283
CC, CT, TT
 
 
15
intergenic
rs10519262
AA, AG, GG
 
 
17
MPO
rs2333227
CC, CT, TT
 
 
rs12316150
 
 
19
APOE
rs429358
CC, CT, TT
 
rs7412
1, 2
19
APOC1
rs4420638
AA, AG, GG
2
 
X
PCDH11X
rs5984894
AA, AG, GG
1
 
Alzheimer's Disease (early onset)
14
PSEN1
 
 
1
PSEN2
 
 
9
ABCA2
rs908832
AA, AG, GG
1
 
 
21
APP
 
Amyotrophic Lateral Sclerosis (ALS)
1
FLJ10986
rs6700125
CC, CT, TT
1
 
rs6690993
AA, AG, GG
1
 
 
rs10493256
 
 
rs6587852
1
 
 
rs1470407
 
 
rs333662
 
 
2
intergenic
rs12473579
1
 
 
rs17027230
1
 
 
2
IL18RAP
rs3771150
1
 
 
7
LOC653748
rs10260404
CC, CT, TT
1
 
 
7
DPP6
rs10239794
CC, CT, TT
1
 
 
7
PON2
rs12704795
1
 
 
7
MAGI2
rs757863
1
 
 
12
intergenic
rs905080
1
 
 
12
intergenic
rs1027615
1
 
 
15
LIPC
rs3825776
TT, CT, CC
1
 
 
17
GRN
rs9897526
 
 
rs34424835
 
 
rs850713
 
 
18
LOXHD1
rs988213
1
 
 
20
intergenic
rs13036957
1
 
 
21
intergenic
rs2836061
1
 
Creutzfeldt-Jakob Disease
11
CTSD
rs17571
AA, AG, GG
1
 
20
PRNP
rs1799990
AA, AG, GG
1
 
Cystic Fibrosis
7
CFTR
i3000001
DD, DI*, II
1
 
Endometriosis
6
ESR1
rs9340799
AA, AG, GG
1
 
G6PD Deficiency
X
G6PD
rs1050828
CC, CT, TT
1
Gallstones
8
ADRB3
rs4994
AA, AG, GG
1
 
Gestational Diabetes
10
TCF7L2
rs7903146
CC, CT, TT
1
 
Glaucoma
15
LOXL1
rs1048661
GG, GT, TT
1
 
rs3825942
CC, CT, TT
1
     
rs2165241
CC, CT, TT
1, 2
 
     
rs1078967
2
 
Glaucoma (open angle)
1
MYOC
rs28936694
1
 
Gout
4
SLC2A9
rs1014290
AA, AG, GG
1
     
rs6449213
CC, CT, TT
1
 
     
rs737267
GG, GT, TT
1
 
Haemochromatosis
6
HFE
rs1800562
AA, AG, GG
1, 2
     
rs1799945
CC, CG, GG
1, 2
 
Haemophilia
X
F8
 
X
F9
Hearing loss (noise-induced)
6
HSP70-hom
rs2227956
1
 
6
HSP70-1
rs1043618
 
6
HSP70-2
rs1061581
Hearing loss (age-related)
1
KCNQ4
 
8
GRHL2
Hearing loss (congenial)
13
GJB2
 
5
TGBF1
Hirschprung's disease
1
ECE1
 
 
2
SIP1
 
 
4
PHOX2B
rs28939716
1
 
 
5
GDNF
 
 
10
RET
rs3026785
1
 
 
rs17158558
1
 
 
rs1800858
1
 
 
rs2435357
1
 
 
13
EDNRB
rs5352
1
 
 
19
NTN
 
 
20
EDN3
rs11570255
1
 
     
rs11570351
1
 
 
22
SOX10
 
Huntington's disease
4
HTT
rs17781557
 
Intrahepatic Cholestasis of Pregnancy
2
ABCB11
rs2287622
AA, AG, GG
1
 
 
10
ABCC2
rs3740066
CC, CT, TT
1
 
Kidney Disease
15
MTHFS
rs6495446
CC, CT, TT
1
 
6
PKHD1
rs28937907
1
     
rs28939099
1
 
     
rs28939383
1
 
 
16
UMOD
rs28934584
1
Kidney stones (hypercalcaemia)
3
CASR
Non-alcoholic fatty liver disease
4
PPARGC1A
rs2290602
GG, GT, TT
 
Nonsyndromic Deafness
1
KCNQ4
rs28937588
     
rs28937589
1
 
     
rs28939710
 
 
4
WFS1
rs28937893
 
 
4
DSPP
rs28929492
 
 
11
TECTA
rs28939691
     
rs28939690
 
 
11
MYO7A
rs28934903
 
13
GJB2
rs28931595
 
14
COCH
rs28938175
 
16
CRYM
rs28929490
Neurofibromatosis type II
22
NF2
Osteoarthritis
1
intergenic
rs4140564
AA, AG, GG
1
 
2
FRZB
rs7775
1
 
 
3
LOC344875
rs7639618
CC, CT, TT
1
 
     
rs9864422
CC, CT, TT
 
     
rs11718863
AA, AT, TT
 
 
20
GDF5
rs143383
CC, CT, TT
1
Osteoporosis
2
QPCT
rs3770748
CC, CT, TT
1
 
11
LRP5
rs4988321
AA, AG, GG
1
 
 
rs3736228
CC, CT, TT
1
 
 
15
CYP19A1
rs17703883
1
 
     
rs16964201
1
 
     
rs12594287
1
 
 
20
BMP2
rs235754
1
 
Otitis
6
TNF
rs1800750
AA, AG, GG
1
 
 
rs361525
AA, AG, GG
1
 
 
7
IL6
rs1800795
AA, AG, GG
1
 
Parkinson's Disease
12
LRRK2
rs34637584
AA, AG, GG
1
     
rs34778348
AA, AG, GG
1
 
 
1
USP24
rs287235
CC, CG, GG
1
 
 
2
USP40
rs838552
1
 
 
4
ADH1C
rs283413
GG, GT, TT
1
 
 
4
SNCA
rs356219
1
 
Placental Abruption
1
F5
rs6025
CC, CT, TT
1
 
Progressive Supranuclear Palsy
11
NR1H3
rs7120118
CC, CT, TT
1
Sarcoidosis
10
ANXA11
rs7091565
 
 
6
TNF
rs1800629
AA, AG, GG
1
 
Sciatica
7
IL6
rs1800795
CC, CG, GG
1
 
rs1800796
CC, CG, GG
1
 
 
rs1800797
AA, AG, GG
1
 
 
rs13306435
AA, AT, TT
 
Sickle-cell Anemia
11
HBB
i3003137
AA, AT*, TT
1
Tourette's Syndrome
12
TPH2
rs4565946
CC, CT, TT
1
 
Uterine Fibroids
6
ESR1
rs9340799
AA, AG, GG
1
 
Wilson's disease
3
CP
rs701753
 
13
ATP7B
rs28942074
1
 
     
rs28942075
1
 
 
rs28942076
1



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